4-Aryldihydropyrimidines via the Biginelli Condensation: Aza-Analogs of Nifedipine-Type Calcium Channel Modulators
نویسندگان
چکیده
منابع مشابه
One-Pot Multi-Component Synthesis of Dihydropyrimidinones via Biginelli Condensation
Three-component reactions have emerged as useful methods because the combinationof three components to generate new products in a single step is extremely economical,among the multi-component reactions. A green, simple, efficient, and cost-effective procedure has been carried out by the synthesis of dihydropyrimidinonesin Biginelli’s condensation of ethyl cyanoacetate, aldehyde and urea or thio...
متن کاملSynthesis and evaluation of a new class of nifedipine analogs with T-type calcium channel blocking activity.
We have synthesized a novel series of 18 dialkyl 1,4-dihydro-4-(2'alkoxy-6'-pentadecylphenyl)-2,6-dimethyl-3,5 pyridine dicarboxylates from anacardic acid, a natural compound found in cashew nut shells, and investigated their blocking action on L- and T-type calcium channels transiently expressed in tSA-201 cells. The IC(50) values for L-type calcium channel block obtained with the series range...
متن کاملCalcium Channel Blockers Nifedipine and Diltiazem Inhibit
We have undertaken a detailed study of the mechanisms of maintenance of intracellular Ca2+ homeostasis in human polymorphonuclear neutrophils (PMN) and its implications for phagocytosis and IgG Fc receptor (FcR) signaling. When PMN were incubated in Ca2+free medium, cytoplasmic calcium concentration ([Ca"+Ii) was markedly depressed and intracellular stores were depleted of calcium. [Ca2+Ii n th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecules
سال: 1998
ISSN: 1420-3049
DOI: 10.3390/30100001